Abstract
The syntheses and biological activities of a novel series of 2,4- and 2,5-disubstituted thiophenes are reported. These analogues have shown excellent affinity and selectivity against alpha(1)-adrenoreceptor subtypes.
MeSH terms
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Adrenergic alpha-Antagonists / chemical synthesis
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Adrenergic alpha-Antagonists / chemistry
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Adrenergic alpha-Antagonists / pharmacology
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Binding Sites
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Humans
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Male
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Molecular Structure
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Prostatic Hyperplasia / drug therapy*
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Structure-Activity Relationship
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Thiophenes / chemical synthesis*
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Thiophenes / chemistry
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Thiophenes / pharmacology*
Substances
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Adrenergic alpha-Antagonists
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Thiophenes